AMPAKINE® Publications
| Article |
J. C. Lauterborn, C. S. Rex, E. Kramar, L. Y. Chen, V. Pandyarajan, G. Lynch, and C. M. Gall Brain-Derived Neurotrophic Factor Rescues Synaptic Plasticity in a Mouse Model of Fragile X Syndrome - J. Neurosci., October 3, 2007; 27(40): 10685 - 10694. |
M. Ogier, H. Wang, E. Hong, Q. Wang, M. E. Greenberg, and D. M. Katz - Brain-Derived Neurotrophic Factor Expression and Respiratory Function Improve after Ampakine Treatment in a Mouse Model of Rett Syndrome - J. Neurosci., October 3, 2007; 27(40): 10912 - 10917. |
L. Y. Chen, C. S. Rex, M. S. Casale, C. M. Gall, and G. Lynch - Changes in Synaptic Morphology Accompany Actin Signaling during LTP - J. Neurosci., May 16, 2007; 27(20): 5363 - 5372. |
G. Lynch, E. A. Kramar, C. S. Rex, Y. Jia, D. Chappas, C. M. Gall, and D. A. Simmons - Brain-Derived Neurotrophic Factor Restores Synaptic Plasticity in a Knock-In Mouse Model of Huntington's Disease - J. Neurosci., April 18, 2007; 27(16): 4424 - 4434. |
C. S. Rex, C.-Y. Lin, E. A. Kramar, L. Y. Chen, C. M. Gall, and G. Lynch - Brain-Derived Neurotrophic Factor Promotes Long-Term Potentiation-Related Cytoskeletal Changes in Adult Hippocampus - J. Neurosci., March 14, 2007; 27(11): 3017 - 3029. |
Christopher S. Rex, Julie C. Lauterborn, Ching-Yi Lin, Eniko A. Kramár, Gary A. Rogers, Christine M. Gall and Gary Lynch - Restoration of Long-Term Potentiation in Middle-Aged Hippocampus After Induction of Brain-Derived Neurotrophic Factor - J Neurophysiol 96: 677-685, 2006. |
Gary Lynch, Eniko A. Kramar, Christopher S. Rex, Yousheng Jia, Danielle Chappas, Christine M. Gall, and Danielle A. Simmons: - Brain-Derived Neurotrophic Factor Restores Synaptic Plasticity in a Knock-In Mouse Model of Huntington’s Disease - The Journal of Neuroscience, April 18, 2007 • 27(16):4424–4434 |
Jun Ren, Betty Y. Poon, Yun Tang, Gregory D. Funk, and John J. Greer - Ampakines Alleviate Respiratory Depression in Rats - Am J Respir Crit Care Med Vol 174. pp 1384–1391, 2006 |
Rongsheng Jin, Suzanne Clark, Autumn M. Weeks, Joshua T. Dudman, Eric Gouaux, and Kathryn M. Partin - Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors - The Journal of Neuroscience, September 28, 2005 • 25(39):9027–9036 |
Linda J. Porrino, James B. Daunais, Gary A. Rogers, Robert E. Hampson, Sam A. Deadwyler - Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates - PLoS Biology | www.plosbiology.org September 2005 | Volume 3 | Issue 9 | e299 0001 |
| Mechanism of Positive Allosteric Modulators Actingon AMPA Receptors Rongsheng Jin, Suzanne Clark, Autumn M. Weeks, Joshua T. Dudman, Eric Gouaux, and Kathryn M. Partin The Journal of Neuroscience September 28, 2005 25(39):9027-9036 |
| Hess US, Whalen SP, Sandoval LM, Lynch G, Gall CM Ampakines reduce methamphetamine-driven rotation and activate neocortex in a regionally selective fashion. Neuroscience. 2003;121(2):509-21 |
| Lauterborn JC, Truonng GT, Baudry M, Bi X, Lynch G, Gall CM Chronic Elevation of Brain Derived Neurotrophic Factor by Ampakines J Pharmacol Exp Ther. 2003 Jul 31 PMID: 12893840 {PubMed - as supplied by publisher] |
| Lin B, Colgin LL, Brucher FA, Arai AC, Lynch G Interactions between recording technique and AMPA receptor modulators Brain Res. 2002 Nov 15;955(1-2):164-173 PMID: 12419533 [PubMed - indexed for MEDLINE] |
| Munirathinam S, Rogers G, Bahr BA Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors elicits neuroprotection after trimethyltin exposure in hippocampus Toxicol Appl Pharmacol. 2002 Dec 1;185(2):111-8 PMID: 12490135 [PubMed - indexed for MEDLINE] |
| Suppiramaniam V, Bahr BA, Sinnarajah S, Owens K, Rogers G Member of the Ampakine class of memory enhancers prolongs the single channel open time of reconstituted AMPA receptors Synapse 2001 May;40(2):154-8 PMID: 11252027 [PubMed - indexed for MEDLINE] |
| Dr. Gary Lynch (2002) Memory enhancement: the search for mechanism-based drugs. Nature Neuroscience Nov. 2002, Vol. 5 Supplement, pp.1035-1038. Electronic reprint permission granted by Nature Publishing Group http://www.nature.com/natureneuroscience |
| Ben A. Bahr, Jennifer Bendiske, Queenie B. Brown, Subramani Munirathinam, Ebru Caba, Markus Rudin, Stephan Urwyler, Andre Sauter, and Gary Rogers (2002) Survival Signaling and Selective Neuroprotection Through Glutamatergic Transmission. Experimental Neurology 174: 37-47. |
| Kessler M, Rogers G, Arai A (2000) The norbornenyl moiety of cyclothiazide determines the preference for flip-flop variants of AMPA receptor subunits. Neurosci Lett 2000 Jun 23;287(2):161-5 |
| Arai AC, Kessler M, Rogers G, Lynch G (2000) Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466. Mol Pharmacol 2000 Oct;58(4):802-13 |
| Lauterborn J, Lynch G, Vanderklish P, Arai A, Gall C (2000) Positive Modulation of AMPA Receptors Inreases Neurotrophin Expression by Hippocampal and Cortical Neurons. Journal of Neuroscience 20 (1): 8-21 |
| Johnson, S.A. et al. (1999) Synergistic Interactions Between AMPAKINEs® and Antipsychotic Drugs. The Journal of Pharmacology and Experimental Therapeutics 289: 392-297. |
| "Hypothesis: Is infantile autism a hypoglutamatergic disorder? Relevance of glutamate -- serotonin interactions for pharmacotherapy" by M.L. Carlsson (Department of Pharmacology, Universitiy of Gotenborg, Gotenborg, Sweden. J Neural Transm (1998) 105:525-535 Arai, A., et.al. (1998) |
| Hampson, R.E. et.al. (1998) Facilitative Effects of the AMPAKINE CX516 on Short-Term Memory in Rats: Enhancement of Delayed-Nonmatch-to-Sample Performance. Journal of Neuroscience 18(7): 2740-2747. |
| Holst, B.D. et.al. (1998) Allosteric Modulation of AMPA-Type Glutamate Receptors Increases Activity of the Promoter for the Neural Cell Adhesion Molecule, N-CAM. Proceedings of the National Academy of Sciences 95(5): 2597-2602. 1. This publication incorrectly cites CX547 as the AMPAKINE employed in the study. CX546 is the compound that was used. |
| Kessler, M. et.al. (1998) Regional Preferences of AMPA Receptor Modulators Determined Through Agonist Binding Autoradiography. Brain Research 783(1): 121-126. |
| Arai, A., Lynch, G. (1998) AMPA Receptor Desensitization Modulates Synaptic Resonses Induced by Repetitive Afferent Stimulation in Hippocampal Slices. Brain Research 799: 235-242. |
| Rogan, M.T. et.al. (1997) AMPA Receptor Facilitation Accelerates Fear Learning without Altering the Level of Conditioned Fear Acquired. Journal of Neuroscience 17 (15): 5928-5935. |
| Ingvar, M. et.al. (1997) Enhancement by an Ampakine of Memory Encoding in Humans. Experimental Neurology 146(2): 553-559. |
| Palmer, L.C. et.al. (1997) Comparison of the Effects of an AMPAKINE With Those of Methamphetamine on Aggregate Neuronal Activity in Cortex Versus Striatum. Molecular Brain Research 46(1-2): 127-135. |
| Lynch, G. et.al. (1997) Evidence that a Positive Modulator of AMPA-Type Glutamate Receptors Improves Delayed Recall in Aged Humans. Experimental Neurology 145(1): 89-92. |
| Hennegriff, M. et.al. (1997) Stable Expression of Recombinant AMPA Receptor Subunits: Binding Affinities and Effects of Allosteric Modulators. Journal of Neurochemistry 68(6): 2424-2434. |
| Deadwyler, et.al. (1996) Hippocampal Ensemble Activity during Spatial Delayed-Nonmatch-to-Sample Performance in Rats. Journal of Neuroscience 16(1):354-372. |
| Larson, J. et.al. (1996) Effects of an AMPA Receptor Modulator on Methamphetamine- induced Hyperactivity in Rats. Brain Research 738(2): 353-356. |
| Arai, A. et.al. (1996) Effects of a Centrally Active Benzoylpyrrolidine Drug on AMPA Receptor Kinetics. Neuroscience 75(2): 573-585. |
| Sirvio, J. et.al. (1996) Effects of Pharmacologically Facilitating Glutamatergic Transmission in the Trisynaptic Intrahippocampal Circuit. Neuroscience 74(4): 1025-1036. |
| Arai, A. et.al. (1996) Effects of a Memory-Enhancing Drug on DL-alpha -amino-3-hydroxy-5-methyl-4- isoxazolepropionic Acid Receptor Currents and Synaptic Transmission in Hippocampus. The Journal of Pharmacology and Experimental Therapeutics 278(2): 627-638. |
| Granger, R. et.al. (1996) Facilitation of Glutamate Receptors Reverses an Age-Associated Memory Impairment in Rats. Synapse 22(4): 332-337. |
| Lynch, G. et.al. (1996) Psychological Effects of a Drug that Facilitates Brain AMPA Receptors. International Clinical Psychopharmacology 11(1): 13-19. |
| Kessler, M., et.al. (1996) Effect of Cyclothiazide on Binding Properties of AMPA-Type Glutamate Receptors: Lack of Competition between Cyclothiazide and GYKI 52466. Molecular Pharmacology 49:123-131. |
| Staubli, U., et.al. (1996) Factors Regulating the Reversibility of Long-Term Potentiation. Journal of Neuroscience 16(2): 853-860. |
| Gold, S., et.al. (1996) Relative Concentrations and Seizure-Induced Changes in mRNAs Encoding Three AMPA Receptor Subunits in Hippocampus and Cortex. Journal of Comparative Neurology 365: 541-555. |
| Larson, J. et.al. (1995) Facilitation of Olfactory Learning by a Modulator of AMPA Receptors. Journal of Neuroscience 15(12): 8023-8030. |
| Shors, T.J. et.al. (1995) Enhanced Glutamatergic Neurotransmission Facilitates Classical Conditioning in the Freely-Moving Rat. Neuroscience Letters 186(2-3): 153-156. |
| Arai, A., et.al. (1995) Effect of Thiocyanate on AMPA Receptor Mediated Responses in Excised Patches and Hippocampal Slices. Neuroscience 66(4):815-827. |
| Staubli, U. et.al. (1994) Centrally Active Modulators of Glutamate Receptors Facilitate the Induction of Long-Term Potentiation In Vivo. Proceedings of the National Academy of Sciences 91(23): 11158-11162. |
| Arai, A. et.al. (1994) A Centrally Active Drug that Modulates AMPA Receptor Gated Currents. Brain Research 638(1-2): 343-346. |
| Staubli, U. et.al. (1994) Facilitation of Glutamate Receptors Enhances Memory. Proceedings of the National Academy of Sciences 91(2): 777-781. |
| Larson, J., et.al. (1994) Effects of cyclothiazide on synaptic responses in slices of adult and neonatal rat hippocampus. NeuroReport 5: 389-392. |
| Granger, R. et.al. (1993) A Drug that Facilitates Glutamatergic Transmission Reduces Exploratory Activity and Improves Performance in a Learning-Dependent Task. Synapse 15(4): 326-329. |
| Hall, R., et.al. (1993) Cyclothiazide decreases [3H]AMPA binding to rat brain membranes: evidence that AMPA receptor desensitization increases agonist affinity. Brain Research 628: 345-348. |