AMPAKINE® Publications
| Article |
Kramár EA, Chen LY, Lauterborn JC, Simmons DA, Gall CM, Lynch G. BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Neurobiol Aging. 2010 Jul 29. [Epub ahead of print] PubMed PMID: 20674095. |
| Simmons DA, Rex CS, Palmer L, Pandyarajan V, Fedulov V, Gall CM, Lynch G. Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4906-11. Epub 2009 Mar 5. PubMed PMID: 19264961; PubMed Central PMCID: PMC2660722. |
| Lauterborn JC, Pineda E, Chen LY, Ramirez EA, Lynch G, Gall CM. Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression. Neuroscience. 2009 Mar 3;159(1):283-95. Epub 2008 Dec 24. PubMed PMID: 19141314; PubMed Central PMCID: PMC2746455. |
J. C. Lauterborn, C. S. Rex, E. Kramar, L. Y. Chen, V. Pandyarajan, G. Lynch, and C. M. Gall Brain-Derived Neurotrophic Factor Rescues Synaptic Plasticity in a Mouse Model of Fragile X Syndrome - J. Neurosci., October 3, 2007; 27(40): 10685 - 10694. |
M. Ogier, H. Wang, E. Hong, Q. Wang, M. E. Greenberg, and D. M. Katz - Brain-Derived Neurotrophic Factor Expression and Respiratory Function Improve after Ampakine Treatment in a Mouse Model of Rett Syndrome - J. Neurosci., October 3, 2007; 27(40): 10912 - 10917. |
G. Lynch, E. A. Kramar, C. S. Rex, Y. Jia, D. Chappas, C. M. Gall, and D. A. Simmons - Brain-Derived Neurotrophic Factor Restores Synaptic Plasticity in a Knock-In Mouse Model of Huntington's Disease - J. Neurosci., April 18, 2007; 27(16): 4424 - 4434. |
Christopher S. Rex, Julie C. Lauterborn, Ching-Yi Lin, Eniko A. Kramár, Gary A. Rogers, Christine M. Gall and Gary Lynch - Restoration of Long-Term Potentiation in Middle-Aged Hippocampus After Induction of Brain-Derived Neurotrophic Factor - J Neurophysiol 96: 677-685, 2006. |
Gary Lynch, Eniko A. Kramar, Christopher S. Rex, Yousheng Jia, Danielle Chappas, Christine M. Gall, and Danielle A. Simmons: - Brain-Derived Neurotrophic Factor Restores Synaptic Plasticity in a Knock-In Mouse Model of Huntington’s Disease - The Journal of Neuroscience, April 18, 2007 • 27(16):4424–4434 |
Rex CS, Lauterborn JC, Lin CY, Kramár EA, Rogers GA, Gall CM, Lynch G. - Restoration of long-term potentiation in middle-aged hippocampus after induction of brain-derived neurotrophic factor. J Neurophysiol. 2006 Aug;96(2):677-85. Epub 2006 May 17. PubMed PMID: 16707719; PubMed Central PMCID: PMC1554892. |
Linda J. Porrino, James B. Daunais, Gary A. Rogers, Robert E. Hampson, Sam A. Deadwyler - Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates - PLoS Biology | www.plosbiology.org September 2005 | Volume 3 | Issue 9 | e299 0001 |
| Mechanism of Positive Allosteric Modulators Actingon AMPA Receptors Rongsheng Jin, Suzanne Clark, Autumn M. Weeks, Joshua T. Dudman, Eric Gouaux, and Kathryn M. Partin The Journal of Neuroscience September 28, 2005 25(39):9027-9036 |
Rex CS, Kramár EA, Colgin LL, Lin B, Gall CM, Lynch G. Long-term potentiation is impaired in middle-aged rats: regional specificity and reversal by adenosine receptor antagonists. J Neurosci. 2005 Jun 22;25(25):5956-66. PubMed PMID: 15976084. |
| Hess US, Whalen SP, Sandoval LM, Lynch G, Gall CM Ampakines reduce methamphetamine-driven rotation and activate neocortex in a regionally selective fashion. Neuroscience. 2003;121(2):509-21 |
| Lauterborn JC, Truonng GT, Baudry M, Bi X, Lynch G, Gall CM Chronic Elevation of Brain Derived Neurotrophic Factor by Ampakines J Pharmacol Exp Ther. 2003 Jul 31 PMID: 12893840 {PubMed - as supplied by publisher] |
| Munirathinam S, Rogers G, Bahr BA Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors elicits neuroprotection after trimethyltin exposure in hippocampus Toxicol Appl Pharmacol. 2002 Dec 1;185(2):111-8 PMID: 12490135 [PubMed - indexed for MEDLINE] |
| Suppiramaniam V, Bahr BA, Sinnarajah S, Owens K, Rogers G Member of the Ampakine class of memory enhancers prolongs the single channel open time of reconstituted AMPA receptors Synapse 2001 May;40(2):154-8 PMID: 11252027 [PubMed - indexed for MEDLINE] |
| Dr. Gary Lynch (2002) Memory enhancement: the search for mechanism-based drugs. Nature Neuroscience Nov. 2002, Vol. 5 Supplement, pp.1035-1038. Electronic reprint permission granted by Nature Publishing Group http://www.nature.com/natureneuroscience |
| Ben A. Bahr, Jennifer Bendiske, Queenie B. Brown, Subramani Munirathinam, Ebru Caba, Markus Rudin, Stephan Urwyler, Andre Sauter, and Gary Rogers (2002) Survival Signaling and Selective Neuroprotection Through Glutamatergic Transmission. Experimental Neurology 174: 37-47. |
| Kessler M, Rogers G, Arai A (2000) The norbornenyl moiety of cyclothiazide determines the preference for flip-flop variants of AMPA receptor subunits. Neurosci Lett 2000 Jun 23;287(2):161-5 |
| Arai AC, Kessler M, Rogers G, Lynch G (2000) Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466. Mol Pharmacol 2000 Oct;58(4):802-13 |
| Lauterborn J, Lynch G, Vanderklish P, Arai A, Gall C (2000) Positive Modulation of AMPA Receptors Inreases Neurotrophin Expression by Hippocampal and Cortical Neurons. Journal of Neuroscience 20 (1): 8-21 |
| Johnson, S.A. et al. (1999) Synergistic Interactions Between AMPAKINEs® and Antipsychotic Drugs. The Journal of Pharmacology and Experimental Therapeutics 289: 392-297. |
| Hampson, R.E. et.al. (1998) Facilitative Effects of the AMPAKINE CX516 on Short-Term Memory in Rats: Enhancement of Delayed-Nonmatch-to-Sample Performance. Journal of Neuroscience 18(7): 2740-2747. |
| Kessler, M. et.al. (1998) Regional Preferences of AMPA Receptor Modulators Determined Through Agonist Binding Autoradiography. Brain Research 783(1): 121-126. |
| Arai, A., Lynch, G. (1998) AMPA Receptor Desensitization Modulates Synaptic Resonses Induced by Repetitive Afferent Stimulation in Hippocampal Slices. Brain Research 799: 235-242. |
| Rogan, M.T. et.al. (1997) AMPA Receptor Facilitation Accelerates Fear Learning without Altering the Level of Conditioned Fear Acquired. Journal of Neuroscience 17 (15): 5928-5935. |
| Ingvar, M. et.al. (1997) Enhancement by an Ampakine of Memory Encoding in Humans. Experimental Neurology 146(2): 553-559. |
| Lynch, G. et.al. (1997) Evidence that a Positive Modulator of AMPA-Type Glutamate Receptors Improves Delayed Recall in Aged Humans. Experimental Neurology 145(1): 89-92. |
| Larson, J. et.al. (1996) Effects of an AMPA Receptor Modulator on Methamphetamine- induced Hyperactivity in Rats. Brain Research 738(2): 353-356. |
| Arai, A. et.al. (1996) Effects of a Centrally Active Benzoylpyrrolidine Drug on AMPA Receptor Kinetics. Neuroscience 75(2): 573-585. |
| Arai, A. et.al. (1996) Effects of a Memory-Enhancing Drug on DL-alpha -amino-3-hydroxy-5-methyl-4- isoxazolepropionic Acid Receptor Currents and Synaptic Transmission in Hippocampus. The Journal of Pharmacology and Experimental Therapeutics 278(2): 627-638. |
| Granger, R. et.al. (1996) Facilitation of Glutamate Receptors Reverses an Age-Associated Memory Impairment in Rats. Synapse 22(4): 332-337. |
| Lynch, G. et.al. (1996) Psychological Effects of a Drug that Facilitates Brain AMPA Receptors. International Clinical Psychopharmacology 11(1): 13-19. |
| Staubli, U., et.al. (1996) Factors Regulating the Reversibility of Long-Term Potentiation. Journal of Neuroscience 16(2): 853-860. |
| Larson, J. et.al. (1995) Facilitation of Olfactory Learning by a Modulator of AMPA Receptors. Journal of Neuroscience 15(12): 8023-8030. |
| Shors, T.J. et.al. (1995) Enhanced Glutamatergic Neurotransmission Facilitates Classical Conditioning in the Freely-Moving Rat. Neuroscience Letters 186(2-3): 153-156. |
| Staubli, U. et.al. (1994) Centrally Active Modulators of Glutamate Receptors Facilitate the Induction of Long-Term Potentiation In Vivo. Proceedings of the National Academy of Sciences 91(23): 11158-11162. |
| Arai, A. et.al. (1994) A Centrally Active Drug that Modulates AMPA Receptor Gated Currents. Brain Research 638(1-2): 343-346. |
| Staubli, U. et.al. (1994) Facilitation of Glutamate Receptors Enhances Memory. Proceedings of the National Academy of Sciences 91(2): 777-781. |